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Wednesday, March 15 • 10:30 - 12:30
Innovation in Compound Management

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Driven by increasing customer demands in the face of limited resources, compound managers need to continually improve equipment, internal processes as well as external interfaces to remain viable in the time-restricted, labor-intensive, highly competitive field of early drug discovery. The same time, technological advances and breakthroughs in compound storage, handling, and quality control don not only offers the solution for existing problems but even provoke the rethinking of existing processes. This session will present case studies from industry sharing firsthand experience with cutting-edge innovation in sample management, as well as perspectives from academic labs on how groundbreaking technologies may shape the future of compound logistics.

10.30 Inge Moelans
Janssen’s Compound Logistics 2016+ Upgrade Project: From Starfish to Octopus

In 2016 Janssen decided to upgrade their Compound Logistics facilities globally.
To  ensure that we deliver the promise and vision that “Compound Logistics is a state of the art global organization  that cares for the Janssen Compound Library and flawlessly feeds all Janssen compound related (early) research activities (internally as well as externally) with high quality compound samples in a standardized manner” a global project has been initiated to enable the implementation of Efficient and State-Off-The-Art Compound Management Infrastructures and Processes to support Drug Discovery Goals. As a result several new hardware and software systems will become available across three Compound Management sites in 2017-2018. The integrated combination of optimized hardware and software systems will lead to reduced cycle times, efficient, standardized & flexible compound processing and high quality samples. 

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10.55 Mark Gulbronson
Metrics, Process Efficiency, and Flexibility

Amgen’s Research Materials Management group was originally built to manage the research small molecule collection. The software, automation, and processes put in place allowed us to grow the collection 10-fold while simultaneously reducing staffing requirements. This presentation explores lessons learned in two areas: Are we efficient? Are we flexible?

Are we efficient? Research Materials Management, as part of a collaborative team, examined the processing and movement of molecules from submission through assay results generation. The analysis identified the impact of distributed Amgen sites and outsourcing partners, internal scheduling, and queue wait times for constrained and unconstrained resources.

Are we flexible? When we looked to apply our proven strategies to biologics inventory management and processes in the biology labs, we were faced with significant challenges. In addition to the new lower temperature storage requirements, the biology labs typically did not use automation, barcodes, standard consumables, or proper inventory systems. In addition, tubes representing years of research were distributed around the world in hundreds of freezers and LN2 tanks. 

11.20 Phil Spencer
Introducing AstraZeneca’s Global Capability for Acoustic Tubes

AstraZeneca is collaborating with Labcyte and others to transform the use and benefit of its automated compound plate production systems in the new UK Centre for Lead Discovery at Cambridge and at its sites in Gothenburg and Boston. Through the development of novel miniaturised liquid storage vessels, dispensing devices and automated workcells, the collaborations will deliver a new global capability for acoustic dispensing direct from sample storage tubes. For the first time, compound screening plates will be produced entirely by acoustic dispensing, completely eliminating pipette-based liquid transfer methods and providing an unparalleled level of quality in the screening data delivered to drug discovery projects.This presentation will cover the drivers for AstraZeneca pursuing this innovative approach and the benefits and impacts for Compound Management and its customers. Details of AstraZeneca’s new global business processes and progress on development of novel technologies with its collaborators will also be included.

11.45 Susan Crimmin

A Sample Management Strategy for the Modern Drug Discovery

Sample management has traditionally been based around small molecule collections and processes.
In the last few years we have come to realize that the Pharma landscape is changing. With that comes increasing challenges but also significant opportunities for sample management organizations to help support that changing landscape.  This talk will focus on the transitions made within GSK to meet the changing face of drug discovery. 

12.10 SNAPSHOT PRESENTATIONS:

Donat Elsener, 
Director of Sales and Marketing, Hamilton Storage

Not Only ‘Think Big’

Dr. Martin Brunner, Principal Scientist Compound Logistics, from Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd Specs


Moderators
avatar for Jan Eickhoff

Jan Eickhoff

Head of Assay Development / Screening, Lead Discovery Center GmbH
Jan Eickhoff studied biochemistry at the University Bayreuth and Imperial College in London, followed by PhD studies at the Max-Planck-Institute of Biochemistry in Martinsried. He started his industrial career in 2001 at Axxima Pharmaceuticals, and GPC Biotech, before he moved to Dortmund in 2008 to build up the screening and sample management department of the Lead Discovery Center GmbH (LDC). Furthermore, he was involved in conceptual... Read More →

Speakers
avatar for Susan Crimmin

Susan Crimmin

Vice president of Discovery Supply, GSK
Dr Sue Crimmin is VP and global head of Discovery Supply at GSK.  This worldwide organization is accountable for the acquisition, development and management of GSK biological (including Human Biological Samples) & small molecule collections and the maintenance & distribution of preclinical, clinical and post clinical trial samples and collections including compliance and QA.  She is a recognized industry expert in sample... Read More →
avatar for Mark Gulbronson

Mark Gulbronson

Director Research Operations, Amgen
Mark Gulbronson, Director Research Operations, is head of Amgen’s Research Materials Management organization. With operations in California and Massachusetts, his team is responsible for the curation and worldwide distribution of Amgen’s small molecule and biologics collections. Mark has contributed to pharmaceutical research for 30 years as a cardiovascular biologist, software developer, and operations manager at Bristol-Myers... Read More →
avatar for Inge Moelans

Inge Moelans

Global Head Compound Logistics, Janssen Research and Development
Inge Moelans is head of the Compound Logistics group within the Discovery Sciences organization at Janssen Research and Development. After completion of her masters in Biology and Chemistry, with specializations in Molecular Biology and Pharmacology, she received a Ph.D. in Sciences at the University of Nijmegen, The Netherlands. In addition, she worked as a post-doc in the Eijkman-Winkler Institute of Medical Microbiology in Utrecht, The... Read More →
avatar for Philip Spencer

Philip Spencer

Team Leader Compound Management, AstraZeneca
Phil Spencer has more than fifteen years experience working in Compound Management. From 2000 he was Head of Compound Management at AstraZeneca’s Charnwood site, where he established an Automated Compound Management Facility to support High Throughput Screening. | | In 2011, Phil moved to the Compound Management group at Alderley Park, where he launched New Molecule Profiling within AstraZeneca’s Open Innovation program, offering... Read More →


Wednesday March 15, 2017 10:30 - 12:30
Music Hall 1