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Tuesday, March 14 • 14:00 - 14:50
Learning from each other - sample logistics in non-small molecule environments Part 2

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The challenges of chemical sample management are shared by several neighbouring disciplines in industry and academia. Whilst each discipline has it’s unique problems, the solutions are often founded on common principles that translate across the broader sample management community. In this session, scientists from a diverse array of sample management disciplines will share their distinct experiences, the challenges they’ve overcome in providing a high quality service to support scientific research and development, and highlight the key factors under consideration for future improvements


14.00 Ida Isaksson
New modalities, new processes: addressing sample management challenges with biologicals in early research

Biologicals (linear peptides, macrocycles, nucleosides, protein, sugars and more) are rapidly becoming ligand options for targets of interest in big pharma drug discovery portfolios, alongside small molecules. How does compound management adapt to the needs of these "new modalities"? Work is in progress in AstraZeneca to answer this question, to implement sustainable processes while ensuring sample quality and data integrity. While some existing processes and IT tools established over the years can be adjusted to fit the new requirements, biologicals pose different challenges compared to small molecules when it comes to storage conditions, solvents and metadata which requires the introduction of new technological capabilities. 

Our current focus is on peptides, proteins and genome editing libraries. Examples of work being undertaken includes sample-specific storage conditions to ensure quality, workflow enhancements in sample management system and introduction of liquid handling systems with multiple fluid capability. Current sample registration system is also developed to cater for different sample properties which enables comparison of screening data from different modalities easily. Together these changes maximize the utilisation of new modalities to support our drug discovery research.

14.30 James Johnson, Manager of the GeneMill facility
Challenges for management and tracking in SynBio





Moderators
avatar for Clive Green

Clive Green

Director, R&D, Discovery Sciences, AstraZeneca
Clive received undergraduate and postgraduate degrees in Chemistry from the University of Nottingham, UK. He then completed postdoctoral research at the University of Pennsylvania, USA, before returning to the UK in 2001 as a medicinal chemistry Team Leader with AstraZeneca. As a medicinal chemist, Clive delivered projects in the Oncology and Cardiovascular disease areas, spanning all phases of drug discovery research. In 2010, he took up the... Read More →

Speakers
JJ

James Johnson

James is currently the Manager of the GeneMill facility, an open-access Synthetic Biology “Foundry”. He read Applied Biochemistry at the University of Liverpool, during which time he worked for F. Hoffmann-La Roche Ltd in Basel, Switzerland. After completing his PhD in Molecular Cell Biology in Mike White’s lab, he went on to work with Bob Burgoyne, Alan Morgan and Jeff Barclay in Liverpool, where he introduced and developed new processes... Read More →

Exhibitors
avatar for Brooks

Brooks

Brooks is a leading worldwide provider of automation and cryogenic solutions for multiple markets including semiconductor manufacturing and life sciences. Brooks Life Science Systems is the global leader in automated sample management solutions that ensure cold-chain integrity from room temperature to -190° C. The company provides unparalleled experience in cold chain management that removes risk and uncertainty from your process... Read More →


Tuesday March 14, 2017 14:00 - 14:50
Music Hall 1